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Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

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Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Asthma-IV: Diagnostic and Management01:30

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Asthma-III: Symptoms and Complications01:24

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Pneumonia II: Pathophysiology01:29

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The pathophysiology of pneumonia involves the following steps:
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Related Experiment Video

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Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
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Pneumococcal Colonization in Children With Persistent Asthma: A Retrospective Cohort.

Liset Olarte1,2, Dithi Banerjee2,3, Douglas Swanson1,2

  • 1From the Department of Pediatrics, Children's Mercy Kansas City, Missouri.

The Pediatric Infectious Disease Journal
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PubMed
Summary

Children with persistent asthma showed lower rates of pneumococcal colonization compared to healthy children. This finding impacts understanding of respiratory illness in pediatric asthma patients.

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Area of Science:

  • Pediatric respiratory health
  • Infectious disease epidemiology
  • Immunology

Background:

  • Asthma is a common chronic condition in children.
  • The impact of asthma on pneumococcal colonization is not well understood.
  • Investigating this link is crucial for managing childhood respiratory illnesses.

Purpose of the Study:

  • To compare pneumococcal colonization rates in children with and without persistent asthma.
  • To determine the serotype distribution of pneumococcus in these children.
  • To understand how asthma influences the carriage of Streptococcus pneumoniae.

Main Methods:

  • Nasal samples were collected from children aged 5-18 with respiratory symptoms.
  • Real-time PCR was used to detect pneumococcal colonization.
  • Multiplex PCR identified pneumococcal serotypes in positive samples.

Main Results:

  • Children with persistent asthma had significantly lower pneumococcal colonization rates (10%) than those without asthma (18.9%).
  • The adjusted odds of colonization were lower in children with asthma (OR 0.4).
  • Common serotypes included 19F, 3, and 6C/6D, with 64.4% being non-PCV13 types.

Conclusions:

  • Persistent asthma is associated with reduced pneumococcal colonization in children.
  • This suggests a potential protective effect of asthma or its management on pneumococcal carriage.
  • Further research is needed to elucidate the mechanisms behind this observation.