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Pneumococcal Colonization in Children With Persistent Asthma: A Retrospective Cohort
Liset Olarte1,2, Dithi Banerjee2,3, Douglas Swanson1,2
1From the Department of Pediatrics, Children's Mercy Kansas City, Missouri.
The Pediatric Infectious Disease Journal
|June 20, 2024
Summary
Children with persistent asthma showed lower rates of pneumococcal colonization compared to healthy children. This finding impacts understanding of respiratory illness in pediatric asthma patients.
Area of Science:
- Pediatric respiratory health
- Infectious disease epidemiology
- Immunology
Background:
- Asthma is a common chronic condition in children.
- The impact of asthma on pneumococcal colonization is not well understood.
- Investigating this link is crucial for managing childhood respiratory illnesses.
Purpose of the Study:
- To compare pneumococcal colonization rates in children with and without persistent asthma.
- To determine the serotype distribution of pneumococcus in these children.
- To understand how asthma influences the carriage of Streptococcus pneumoniae.
Main Methods:
- Nasal samples were collected from children aged 5-18 with respiratory symptoms.
- Real-time PCR was used to detect pneumococcal colonization.
- Multiplex PCR identified pneumococcal serotypes in positive samples.
Main Results:
- Children with persistent asthma had significantly lower pneumococcal colonization rates (10%) than those without asthma (18.9%).
- The adjusted odds of colonization were lower in children with asthma (OR 0.4).
- Common serotypes included 19F, 3, and 6C/6D, with 64.4% being non-PCV13 types.
Conclusions:
- Persistent asthma is associated with reduced pneumococcal colonization in children.
- This suggests a potential protective effect of asthma or its management on pneumococcal carriage.
- Further research is needed to elucidate the mechanisms behind this observation.
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