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Structural and functional connectivity associations with anterior cingulate sulcal variability.

Luke Harper1, Olof Strandberg2, Nicola Spotorno2

  • 1Clinical Memory Research Unit, Department of Clinical Sciences, Medical Sciences, Neuroscience, Lund University, Sölvegatan 19, 22100, Lund, Sweden. l.harper@doctors.org.uk.

Brain Structure & Function
|June 20, 2024
PubMed
Summary

The presence of a left paracingulate sulcus in healthy adults is linked to altered brain connectivity. This sulcation impacts both structural and functional connections within the brain.

Keywords:
CingulateFunctional ConnectivityParacingulateResting-stateSulcation

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Area of Science:

  • Neuroscience
  • Human Anatomy
  • Brain Connectivity

Background:

  • Sulcation, specifically the development of the paracingulate sulcus in the anterior cingulate, occurs late in gestation and influences cognitive functions.
  • Variations in brain structure, such as the presence or absence of the paracingulate sulcus, may have implications for neurological conditions.

Purpose of the Study:

  • To investigate the impact of the presence of a paracingulate sulcus on structural and functional brain connectivity in healthy adults.
  • To explore how ipsilateral paracingulate sulcal presence affects fractional anisotropy, radial diffusivity, and tract volume.
  • To examine differences in resting-state functional connectivity patterns associated with paracingulate sulcal presence.

Main Methods:

  • Cross-sectional study analyzing task-free resting-state functional connectivity and diffusion-weighted imaging data.
  • Cohort included 129 healthy adults under 60 years old.
  • Analysis focused on the association between the presence of a left paracingulate sulcus and specific brain connectivity metrics.

Main Results:

  • Left paracingulate sulcal presence correlated with reduced fractional anisotropy in the left cingulum bundle and peri-genual/dorsal segments, indicating less coherent structural organization.
  • Increased radial diffusivity and tract volume in the left peri-genual region were observed with left paracingulate sulcal presence, suggesting denser U-fibers.
  • Individuals lacking a left paracingulate sulcus exhibited greater network dispersity, characterized by a significant frontal functional connectivity component.

Conclusions:

  • The presence of a left paracingulate sulcus is associated with distinct local structural and functional connectivity patterns in healthy adults.
  • These alterations may stem from a local network utilizing short association fibers.
  • Findings highlight a novel link between brain sulcation and connectivity, relevant for understanding neurological variations.