Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunological Memory01:23

Immunological Memory

590
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
590
Vaccinations01:51

Vaccinations

44.4K
Overview
44.4K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

799
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
799
Active versus Passive Immunity01:31

Active versus Passive Immunity

622
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
622
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

6.5K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
6.5K
What is the Immune System?01:38

What is the Immune System?

111.2K
Overview
111.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Evolving Landscape of JAK-STAT Inhibition in the Treatment of Immune Mediated Inflammatory Diseases.

The Journal of allergy and clinical immunology·2026
Same author

Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells.

The Journal of experimental medicine·2026
Same author

Asymmetry and redundancy of STAT5 paralogs across CD8<sup>+</sup> T cell differentiation states.

Communications biology·2026
Same author

A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation.

The Journal of experimental medicine·2026
Same author

Type I Interferon Signature is Associated With Lung Disease, Drug-Associated Immune Reactions, and Genetic Variation in Interferon-Linked Pathways in Still Disease.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Type I interferon-mediated autoinflammation in two unrelated patients due to a proximal intronic splice site variant in <i>DNASE2</i>.

Research square·2025
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
See all related articles

Related Experiment Video

Updated: Jun 23, 2025

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.2K

JAKing up immunity.

Massimo Gadina1, John J O'Shea2

  • 1Translational Immunology Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.

Science (New York, N.Y.)
|June 20, 2024
PubMed
Summary
This summary is machine-generated.

Janus kinase (JAK) inhibitors enhance the body's ability to fight cancer. These targeted therapies are crucial for improving antitumor responses in various cancer treatments.

More Related Videos

Author Spotlight: Exploring Strategies for Successful Immune Response Against Tumors
05:58

Author Spotlight: Exploring Strategies for Successful Immune Response Against Tumors

Published on: August 16, 2024

2.8K
Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

10.6K

Related Experiment Videos

Last Updated: Jun 23, 2025

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.2K
Author Spotlight: Exploring Strategies for Successful Immune Response Against Tumors
05:58

Author Spotlight: Exploring Strategies for Successful Immune Response Against Tumors

Published on: August 16, 2024

2.8K
Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

10.6K

Area of Science:

  • Immunology
  • Oncology
  • Pharmacology

Background:

  • Janus kinase (JAK) signaling pathways are critical in immune responses and cellular communication.
  • Dysregulation of JAK pathways is implicated in various cancers and inflammatory conditions.
  • Targeting JAK signaling offers a potential strategy for modulating antitumor immunity.

Purpose of the Study:

  • To investigate the impact of Janus kinase (JAK) inhibitors on antitumor responses.
  • To evaluate the efficacy of JAK inhibition in cancer therapy.

Main Methods:

  • Preclinical cancer models were treated with JAK inhibitors.
  • Immune cell populations and cytokine profiles were analyzed.
  • Tumor growth and survival rates were assessed.

Main Results:

  • JAK inhibitors significantly enhanced immune cell infiltration into tumors.
  • Key pro-inflammatory cytokines associated with antitumor immunity were upregulated.
  • Treatment with JAK inhibitors led to reduced tumor growth and improved survival.

Conclusions:

  • Janus kinase (JAK) inhibitors demonstrate a significant role in augmenting antitumor immune responses.
  • Targeting JAK pathways represents a promising therapeutic approach for cancer treatment.