Related Experiment Video

Updated: Jun 23, 2025

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
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Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Published on: March 5, 2022

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Recent insights into N6-methyladenosine during viral infection

Stacy M Horner1, Jordan V Reaves2

  • 1Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

Current Opinion in Genetics & Development
|June 20, 2024
PubMed

Insights

N6-methyladenosine (m6A) RNA modification impacts viral infections by altering viral and cellular mRNA. This review details m6A

Area of Science:

  • Molecular Biology
  • Virology
  • Epigenetics

Background:

  • N6-methyladenosine (m6A) is a prevalent RNA modification.
  • m6A influences RNA metabolism and function.
  • m6A plays a role in host-pathogen interactions.

Purpose of the Study:

  • To review the mechanisms of m6A in viral infection.
  • To highlight emerging concepts in m6A regulation of viruses.
  • To summarize m6A's role in SARS-CoV-2 infection.

Main Methods:

  • Literature review of recent studies.
  • Analysis of m6A's impact on viral and cellular mRNA.
  • Focus on m6A machinery proteins and innate immunity.

Main Results:

  • m6A regulates viral infection through diverse mechanisms.
  • Viral infection alters m6A machinery protein localization and function.
  • m6A modulates antiviral innate immunity.
  • Specific viral infections are differentially regulated by m6A.

Conclusions:

  • m6A is a critical regulator of viral infections.
  • Understanding m6A's role in SARS-CoV-2 provides insights.
  • This review offers a snapshot of current m6A research in virology.

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