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A cone-beam optical CT based on a convergent light source - Characterization and optimization.

M A Silveira1, J F Pavoni1, O Baffa1

  • 1Departamento de Física, FFCLRP, University of São Paulo-USP, Ribeirão Preto, SP, Brazil.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
|June 20, 2024
PubMed
Summary

This study developed an economical cone-beam optical computed tomography scanner for 3D dosimetry. The system uses a convergent beam to improve image quality and accurately measure radiation doses for quality assurance.

Keywords:
3D-dosimetryCone-beam optical CTGel dosimetryOptical CT

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Area of Science:

  • Medical Physics
  • Optical Engineering
  • Radiotherapy Physics

Background:

  • Accurate 3D dosimetry is crucial for radiotherapy quality assurance.
  • Traditional dosimetry methods can be time-consuming and lack spatial resolution.
  • Optical computed tomography (OCT) offers a promising alternative for 3D dose verification.

Purpose of the Study:

  • To develop and validate an economical cone-beam optical computed tomography (OCT) scanner for 3D dosimetry.
  • To optimize the OCT system using a convergent light beam to minimize stray light and enhance image quality.
  • To assess the dosimetry performance of the developed OCT system for clinical applications.

Main Methods:

  • A cone-beam OCT system was designed using a Fresnel lens and point-like light source to create a convergent beam.
  • Optical performance was evaluated using modulation transfer function (MTF) and stray-to-primary ratio measurements.
  • Reconstruction quality was assessed using SIRT-TV, optimizing regularization parameters for contrast-to-noise ratio (CNR).
  • Dosimetry performance was validated by measuring percentage depth dose (PDD) using FXO-f gel dosimeter and comparing with ionization chamber data.

Main Results:

  • The OCT system achieved MTF values of >=50% and a stray-to-primary ratio below 0.1.
  • Reconstructions exhibited low noise and artifacts, with optimal CNR achieved at a regularization parameter (λ) of 0.01.
  • Optical CT-derived attenuation coefficients closely matched spectrometer measurements (within 1.2%).
  • PDD measurements using the FXO-f gel dosimeter showed excellent agreement with ionization chamber data (<1.2% difference), with a dose resolution of 0.1 Gy.

Conclusions:

  • The developed cone-beam OCT system, optimized with a convergent beam, is suitable for 3D quality assurance in clinical radiotherapy.
  • This economical OCT scanner provides accurate and efficient 3D dosimetry, enhancing treatment verification.
  • The study demonstrates the potential of OCT for routine clinical implementation in radiation therapy.