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Tracking defensive states with prefrontal dynorphin-expressing neurons
Thomas Bienvenu1, Cyril Dejean2, Cyril Herry2
1University Bordeaux, Neurocentre Magendie, U1215, 146 Rue Léo-Saignat, 33077 Bordeaux, France; INSERM, Neurocentre Magendie, U1215, 146 Rue Léo-Saignat, 33077 Bordeaux, France; Centre de Référence Régional des Pathologies Anxieuses et de la Dépression, Pôle de Psychiatrie Générale et Universitaire, Centre Hospitalier Charles Perrens, Bordeaux, France.
Abstract:
The dynamic suppression of threat-related behavior as a function of environmental constraint is critical for survival in mammals, yet the neurobiological underpinnings remain largely unknown. In this issue of Neuron, Wang et al.1 identified prefrontal dynorphin-expressing neurons as key elements for tracking threat-related behavioral states and regulating fear suppression.
