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Published on: February 21, 2016
Ex vivo Study of Partial Bladder Resection in a Porcine Model
Aleksander Kielbik1, Timo Hoffmans2, Bastian Amend3
1Department of Urology, University Hospital of Tübingen, Tübingen, Germany, aleksander.kielbik@med.uni-tuebingen.de.
Introduction:
Partial cystectomy aims to preserve bladder function, yet its urodynamic impacts remain unclear. We investigate these effects using an ex vivo porcine model, evaluating bladder volume, compliance, and wall thickness, alongside with thermal damage after bi- and monopolar resection.
Methods:
Within an artificial human pelvis, we conducted partial bladder wall resections (5 cm2, 10 cm2). Urodynamic tests and sonography assessed volume, compliance, and thickness changes. Traction force for catheter retrieval and thermal collagen destruction were measured.
Results:
Bladder compliance decreased by 1.12 and 1.5 after 5 cm2 and 10 cm2 resections, respectively, with volume reductions of 3-6% and 10-18%. Wall thickness decreased by 20% and 30% post-resection. Comparable thermal damage was observed with mono- and bipolar resection methods.
Conclusion:
Our study outlines urodynamic impacts and technical considerations of partial cystectomy, affirming its endoscopic feasibility while highlighting potential bladder dysfunction risks.
