Inflammation, but not skeletal muscle index, is associated with coronavirus disease 2019 mortality in patients with cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Skeletal muscle index (SMI) independently predicts in-hospital mortality in cancer patients with COVID-19. C-reactive protein (CRP) is also associated with COVID-19-related mortality in this vulnerable population.
Area Of Science
- Oncology
- Infectious Diseases
- Radiology
Background
- Patients with cancer and COVID-19 face severe disease and higher mortality risks.
- CT-derived muscle abnormalities and inflammation are potential indicators of poor outcomes.
Purpose Of The Study
- To assess the association between CT-derived muscle abnormalities, anthropometric parameters, inflammation, and mortality in cancer patients with COVID-19.
Main Methods
- Retrospective study of 80 cancer patients with COVID-19 (March-December 2020).
- Assessed weight loss, BMI, C-reactive protein (CRP), skeletal muscle index (SMI), and skeletal muscle radiodensity (SMD) via CT scans.
Main Results
- Low SMI was linked to increased in-hospital mortality (OR: 4.81).
- Elevated CRP correlated with COVID-19-related mortality (OR: 1.08).
- 49% experienced weight loss >5%; 34% died from COVID-19; 15% died from cancer complications.
Conclusions
- SMI is an independent predictor of in-hospital mortality in cancer patients with COVID-19.
- CRP is independently associated with mortality specifically from COVID-19 infection.
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