Prognostic value of body composition in patients with digestive tract cancers: A prospective cohort study of 8,267 adults from China
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View abstract on PubMed
Summary
This summary is machine-generated.A large skeletal muscle area indicates a better prognosis for digestive tract cancer patients. Conversely, cancer cachexia and sarcopenia are linked to a poorer outlook, guiding personalized preoperative assessments.
Area Of Science
- Oncology
- Radiology
- Body Composition Analysis
Background
- Prognostic value of body composition in digestive tract cancers is not fully understood.
- Computed tomography (CT) derived parameters require further characterization.
Purpose Of The Study
- To investigate the prognostic value of body composition parameters and phenotypes in patients with digestive tract cancers.
- To correlate body composition with clinical outcomes.
Main Methods
- Prospective cohort study of 8267 patients with digestive tract cancers.
- CT scans used to quantify skeletal muscle (SM), subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) areas.
- Phenotypes including sarcopenia, cancer cachexia, and sarcopenic obesity were determined; overall survival analyzed using Kaplan-Meier and Cox proportional hazards models.
Main Results
- Larger SM area showed a favorable prognosis (lower mortality risk).
- Sarcopenia and cancer cachexia were associated with significantly poorer overall survival, particularly in male patients.
- Prognostic value varied across different digestive tract cancer types.
Conclusions
- Increased skeletal muscle area is a favorable prognostic indicator in digestive tract cancers.
- Cancer cachexia and sarcopenia are indicators of poor prognosis.
- Body composition assessment offers valuable insights for personalized preoperative risk stratification.
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