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TRPS1 expression in breast angiosarcoma.

Tamás Pancsa1, Boglárka Pósfai1, Anna Schubert1

  • 1Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.

Virchows Archiv : an International Journal of Pathology
|June 20, 2024
PubMed
Summary
This summary is machine-generated.

Trichorhinophalangeal syndrome protein 1 (TRPS1) is present in 60% of breast angiosarcoma (AS) cases. This finding challenges TRPS1

Keywords:
AngiosarcomaBreastImmunohistochemistryTRPS1

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Area of Science:

  • Oncology
  • Pathology
  • Biomarkers

Background:

  • Breast angiosarcoma (AS) is a rare mesenchymal neoplasm with diagnostic challenges.
  • Morphological overlap with other tumors and limited diagnostic material can complicate AS diagnosis.
  • The specificity of trichorhinophalangeal syndrome protein 1 (TRPS1) as a breast carcinoma marker is under scrutiny.

Purpose of the Study:

  • To investigate the expression of TRPS1 in breast angiosarcoma.
  • To evaluate the diagnostic utility of TRPS1 in differentiating breast AS from other tumors.
  • To assess the reliability of TRPS1 as a specific marker for breast malignancies.

Main Methods:

  • Retrospective analysis of breast angiosarcoma cases.
  • Immunohistochemical staining for TRPS1 expression.
  • Consensus scoring by four independent pathologists.
  • Statistical analysis of TRPS1 expression patterns and inter-observer agreement.

Main Results:

  • TRPS1 expression was observed in 60% of breast angiosarcoma cases.
  • Twelve out of 35 AS cases were unequivocally TRPS1-positive.
  • Significant inter-observer disagreement (kappa=0.76) was noted in nine cases, highlighting diagnostic uncertainty.
  • Forty percent of AS cases lacked TRPS1 expression.

Conclusions:

  • TRPS1 is expressed in a substantial proportion of breast angiosarcomas, questioning its specificity.
  • A comprehensive diagnostic approach is crucial for evaluating breast AS.
  • TRPS1-positive entities should be considered in the differential diagnosis of breast lesions.