Related Experiment Video
Updated: Jun 23, 2025
07:34
Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
Published on: December 16, 2022
2.2K
Circadian-driven tissue specificity is constrained under caloric restricted feeding conditions
Renrui Chen1, Ziang Zhang1, Junjie Ma1
1CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Communications Biology
|June 20, 2024
Summary
Approximately 35% of tissue-specific genes are influenced by the circadian clock, impacting aging and longevity. Understanding this circadian-affected tissue specificity is key to unlocking genomic mechanisms of longevity.
Area of Science:
- Genomics
- Chronobiology
- Aging Research
Background:
- Tissue specificity is crucial for organ function and biological processes like aging.
- The circadian clock regulates many biological processes, but its role in tissue specificity is unclear.
Purpose of the Study:
- To investigate the overlap between tissue-specific genes and circadian regulation.
- To explore the functional and genomic implications of circadian-affected tissue specificity in aging and longevity.
Main Methods:
- Analysis of multi-omics data on circadian rhythms in mice.
- Identification of genes affected by circadian regulation within specific tissues.
- Examination of gene expression patterns, sequencing data, and network modules.
Main Results:
- Around 35% of tissue-specific genes are directly influenced by circadian rhythms.
- These genes show higher expression, are linked to metabolism in hepatocytes, and have unique long-read sequencing features.
- Circadian-affected tissue-specific genes are significantly associated with aging and longevity, and their expression responds to caloric restriction.
Conclusions:
- Circadian-affected tissue specificity plays a critical role in the genomic regulation of aging and longevity.
- Modulating these specific genes offers a pathway to understanding and potentially influencing longevity through circadian mechanisms.
