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Published on: February 18, 2012
Consensus definition and diagnostic criteria for neonatal encephalopathy-study protocol for a real-time modified
Aoife Branagan1,2,3,4, Tim Hurley1,2,4, Fiona Quirke4,5
1Discipline of Paediatrics, Trinity College Dublin, the University of Dublin, Dublin, Ireland.
This study establishes a consensus definition for Neonatal Encephalopathy (NE) using a Delphi approach. This will improve research consistency and communication for hypoxic-ischaemic encephalopathy in newborns.
Area of Science:
- Neonatal Medicine
- Neurology
- Clinical Research Methodology
Background:
- Neonatal encephalopathy (NE) is a clinical syndrome in term infants with disturbed neurological function of cerebral origin.
- NE has heterogeneous causes, including peripartum hypoxic-ischaemic events.
- Inconsistent terminology and diagnostic criteria for NE hinder research and family communication.
Purpose of the Study:
- To establish a consensus definition and diagnostic criteria for Neonatal Encephalopathy (NE).
- To improve the uniformity of terminology used in NE research and clinical practice.
Main Methods:
- A systematic literature review to assess current terminology in NE trials.
- An online Real-time Delphi survey guided by an international steering group.
- A consensus meeting to finalize terminology and diagnostic criteria for NE.
Main Results:
- The study aims to achieve a consensus definition and diagnostic criteria for NE.
- The Delphi approach will synthesize expert opinions to address definitional inconsistencies.
- A finalized definition will be disseminated to the neonatal community.
Conclusions:
- A consensus-based definition of NE will enhance research comparability.
- Standardized criteria will improve communication among healthcare professionals and with families.
- The DEFINE project's outcomes will benefit research, clinical practice, and parental experience in neonatal care.
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