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Chronic Obstructive Pulmonary Disease01:22

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  11. Chronic Obstructive Pulmonary Disease Affects Outcome In Surgical Patients With Perioperative Organ Injury: A Retrospective Cohort Study In Germany

Chronic obstructive pulmonary disease affects outcome in surgical patients with perioperative organ injury: a retrospective cohort study in Germany

Nadine Hochhausen1, Mare Mechelinck2, Andreas Kroh3

  • 1Department of Anesthesiology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany. nhochhausen@ukaachen.de.

Respiratory Research
|June 20, 2024

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Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
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View abstract on PubMed

Summary
This summary is machine-generated.

Chronic obstructive pulmonary disease (COPD) significantly increases mortality and hospital stay for surgical patients experiencing perioperative organ injury (POI). Patients with COPD and acute liver injury (ALI) face particularly severe outcomes.

Area of Science:

  • Medical research
  • Surgical outcomes
  • Pulmonology

Background:

  • The impact of chronic obstructive pulmonary disease (COPD) on perioperative organ injury (POI) outcomes is under-researched.
  • POI encompasses conditions like delirium, stroke, myocardial infarction, ARDS, ALI, and AKI.

Purpose of the Study:

  • To investigate the association between COPD and outcomes in surgical patients with POI.
  • To compare in-hospital mortality, hospital length of stay (HLOS), and ventilation time (VT) in patients with and without COPD.

Main Methods:

  • Retrospective cohort study of surgical patients in Germany (2015-2019).
  • Analysis of data from 1,642,377 surgical cases with POI.
  • Comparison of outcomes between patients with and without COPD.
Keywords:
Chronic obstructive pulmonary diseaseIn-hospital mortalityPerioperative organ injury

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Main Results:

  • 10.8% of POI patients had COPD.
  • COPD patients had higher in-hospital mortality (20.6% vs. 15.8%) and longer HLOS (21 vs. 16 days) and VT (199 vs. 125 hours).
  • COPD was associated with a 1.19-fold increased risk of in-hospital mortality in POI patients. Acute kidney injury (AKI) was most common (57.8%), while acute liver injury (ALI) had the highest mortality (54.2%).

Conclusions:

  • COPD is linked to increased mortality, HLOS, and VT in surgical patients with POI.
  • Patients with ALI are particularly vulnerable to the negative effects of COPD on outcomes.