Graph analysis uncovers an opposing impact of methylphenidate on connectivity patterns within default mode network
Maryana Daood1,2, Noa Magal1, Leehe Peled-Avron3,4
1School of Psychological Sciences, University of Haifa, 199 Aba Khoushy Ave. Mount Carmel, Haifa, 31905, Israel.
Behavioral and Brain Functions : BBF
|June 20, 2024
Summary
Methylphenidate (MPH) alters Default Mode Network (DMN) connectivity, impacting distinct sub-networks differently. These changes in brain connectivity may explain MPH
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Neuroimaging
Background:
- The Default Mode Network (DMN) comprises functionally distinct sub-networks.
- Methylphenidate (MPH) modulates impulsive behavior, but its effect on DMN connectivity is unclear.
Purpose of the Study:
- To investigate MPH's impact on DMN sub-network connectivity.
- To correlate DMN connectivity changes with impulsivity.
Main Methods:
- Resting-state fMRI in 55 healthy adults under MPH and placebo.
- Graph modularity analysis to identify DMN sub-networks based on MPH effects.
Main Results:
- MPH decreased DMN connectivity with auditory, cinguloopercular, and somatomotor networks; increased parietomedial network connectivity.
- DMN fractionated into two sub-networks with opposing MPH connectivity changes.
- Decreased DMN-cinguloopercular connectivity linked to higher impulsivity.
Conclusions:
- MPH has opposing effects on distinct DMN sub-networks.
- MPH-induced DMN connectivity changes may underlie its effects on impulsivity.
