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Related Concept Videos

Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

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Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
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Endoscopic Procedures II: Colonoscopy01:25

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The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
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Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

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Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
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  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. White Spots Around Colorectal Tumors Are Cancer-related Findings And May Aid Endoscopic Diagnosis: A Prospective Study In Japan

White spots around colorectal tumors are cancer-related findings and may aid endoscopic diagnosis: a prospective study in Japan

Kai Korekawa1, Yusuke Shimoyama1, Fumiyoshi Fujishima2

  • 1Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Clinical Endoscopy
|June 20, 2024

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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
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Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
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View abstract on PubMed

Summary
This summary is machine-generated.

White spots (WS) observed during endoscopy are associated with colorectal cancer. These findings, identified as fat-laden macrophages, can aid in diagnosing cancerous lesions and may become a future criterion for endoscopic resection.

Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • White spots (WS) around colorectal tumors are infrequently reported and their clinical significance is unclear.
  • Investigating WS is crucial for understanding their role in colorectal lesion diagnosis.

Purpose of the Study:

  • To determine the clinical and pathological significance of white spots (WS) in colorectal tumors.
  • To evaluate the utility of WS as a diagnostic marker during endoscopy.

Main Methods:

  • Analysis of clinical data from 3,869 patients with epithelial tumors.
  • Clinicopathological analysis of 759 adenomas or carcinomas undergoing endoscopic resection.
  • Detailed pathological examination of white spots (WS).

Main Results:

Keywords:
AdenomaColorectal neoplasmsColorectal tumorsEndoscopic diagnosis

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  • White spots (WS) were present in 9.3% of all lesions and 25% of adenoma/early carcinoma cases.
  • WS-positive lesions showed a higher cancer proportion and larger diameter than WS-negative lesions.
  • Positive WS, flat lesions, and tumor diameter ≥5 mm were significant risk factors for carcinogenesis; WS are fat-laden macrophages.

Conclusions:

  • White spots (WS) are associated with colorectal cancer.
  • WS can serve as a novel criterion for endoscopic resection in future clinical practice.
White spots