Related Experiment Video

Updated: May 9, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.2K

Independent causal effect of migraines on Alzheimer's disease risk: a multivariate Mendelian randomization study

Chengfeng Xu1, Wen Wu2, Yuchao Fan1

  • 1Department of Anesthesiology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.

Frontiers in Neurology
|June 21, 2024
PubMed
Abstract

Insights

Genetically predicted migraine is linked to an increased risk of Alzheimer's Disease (AD). However, this association disappears when accounting for factors like blood pressure and tumor necrosis factor alpha.

Area of Science:

  • Neuroscience
  • Genetics
  • Epidemiology

Background:

  • Observational studies on migraine and Alzheimer's Disease (AD) have yielded contradictory results.
  • Previous findings were limited by confounding factors and potential reverse causation.

Purpose of the Study:

  • To investigate the causal relationship between migraine and Alzheimer's Disease (AD) risk.
  • To assess the independent impact of migraine on AD risk using Mendelian Randomization.

Main Methods:

  • Utilized Univariable Mendelian Randomization (UVMR) with large case-control datasets for migraine and AD.
  • Performed meta-analysis to synthesize results from multiple cohorts.
  • Employed Multivariable Mendelian Randomization (MVMR) to adjust for 35 potential AD risk factors.

Main Results:

  • Meta-analysis suggested a causal link between genetically predicted migraine and heightened AD risk (OR [95% CI]: 1.54 [1.18, 2.00], p < 0.01).
  • After adjusting for diastolic blood pressure and tumor necrosis factor alpha, the association between migraine and AD risk was no longer significant.

Conclusions:

  • Genetically predicted migraine shows a significant correlation with elevated Alzheimer's Disease risk.
  • The independent effect of migraine on AD risk is not supported after controlling for key confounding factors.
Keywords:
Alzheimer’s diseasecausal effectmeta-analysismigrainemultivariable Mendelian randomizationunivariable Mendelian randomization

More Related Videos

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

14.9K
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

7.9K

Related Concept Videos

Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...