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Urinary beta 2-microglobulin, antimicrobial chemotherapy and infectious diseases
Upsala Journal of Medical Sciences
|January 1, 1985
Summary
Aminoglycoside antibiotics can cause beta 2-microglobulinuria by impairing kidney function. Fever also temporarily increases beta 2-microglobulin in urine, making it unreliable for diagnosing kidney issues in infections.
Area of Science:
- Nephrology
- Pharmacology
- Clinical Chemistry
Background:
- Beta 2-microglobulinuria is a marker of tubular dysfunction.
- Antibiotics, particularly aminoglycosides, and febrile conditions can affect renal function.
Purpose of the Study:
- To review the literature on beta 2-microglobulinuria during antibiotic treatment and febrile conditions.
- To evaluate the utility of urinary beta 2-microglobulin as a marker for nephrotoxicity and renal involvement in infections.
Main Methods:
- Literature review of studies investigating beta 2-microglobulinuria.
- Analysis of factors influencing urinary beta 2-microglobulin levels.
Main Results:
- Aminoglycoside treatment commonly causes beta 2-microglobulinuria, indicating impaired tubular reabsorption.
- Urinary beta 2-microglobulin increases are not predictive of individual clinical nephrotoxicity.
- Fever causes temporary tubular dysfunction, increasing beta 2-microglobulinuria, likely explaining its presence in pyelonephritis.
Conclusions:
- Urinary beta 2-microglobulin is useful for comparing the nephrotoxic potential of different aminoglycosides and other antimicrobials.
- Beta 2-microglobulinuria is not a reliable indicator for determining renal involvement in urinary tract infections due to confounding factors like fever.