Survival Analysis of Elderly Patients With Laryngeal Cancer After Total Laryngectomy: A Retrospective Cohort Study
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View abstract on PubMed
Summary
This summary is machine-generated.This study shows that tumor-node-metastasis (TNM) staging significantly impacts overall survival for elderly patients undergoing total laryngectomy for laryngeal cancer (LC). Early diagnosis is crucial for improving survival rates in this demographic.
Area Of Science
- Oncology
- Otorhinolaryngology
- Geriatric Medicine
Background
- Laryngeal cancer (LC) is a significant health concern, particularly in elderly populations.
- Total laryngectomy is a primary treatment modality for advanced LC.
- Understanding factors influencing survival post-laryngectomy is critical for patient management.
Purpose Of The Study
- To investigate the overall survival (OS) of elderly patients (>65 years) after total laryngectomy for LC.
- To analyze the impact of tumor-node-metastasis (TNM) staging on the OS of these patients.
- To identify key prognostic factors affecting survival in elderly LC patients.
Main Methods
- Retrospective cohort study of 75 elderly patients who underwent total laryngectomy for LC (2000-2015).
- Survival analysis using Kaplan-Meier estimator and Log-rank test.
- Data collected included patient demographics, tumor characteristics, TNM staging, and treatment details.
Main Results
- Predominantly male (97.3%) patients with a mean age of 73.88 years; high prevalence of smoking (96%) and alcohol use (54.7%).
- Five-year OS rate was 44.6%, significantly influenced by TNM stage (Stage II: 62.5%, Stage III: 55.8%, Stage IV: 32.4%; p=0.039).
- Older age (>75 years) was associated with lower OS (34.7%) compared to younger elderly patients (65-75 years: 51.7%; p=0.039).
Conclusions
- TNM staging is a significant determinant of overall survival in elderly patients undergoing total laryngectomy for laryngeal cancer.
- Advanced TNM stages and older age are associated with poorer survival outcomes.
- Emphasizes the critical need for early diagnosis and intervention to improve survival rates for elderly LC patients.
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