Diagnostic and prognostic significance of keloid-like collagen remodeling patterns in the extracellular matrix of colorectal cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Keloid-like collagen (KC) in colorectal cancer (CRC) stroma is a significant prognostic indicator. Increased KC (>30%) in stage II/III CRC predicts worse 5-year recurrence-free survival, highlighting its diagnostic and prognostic value.
Area Of Science
- Oncology
- Pathology
- Cancer Research
Background
- The desmoplastic reaction in colorectal cancer (CRC) is a key prognostic factor.
- Stromal heterogeneity in intermediate desmoplastic reactions presents diagnostic challenges.
- Keloid-like collagen (KC) is a component of this heterogeneous stroma.
Purpose Of The Study
- To evaluate the diagnostic and prognostic significance of keloid-like collagen (KC) histophenotyping.
- To quantitatively assess KC presence in the invasive margin stroma of stage II/III CRC.
- To correlate KC levels with patient survival outcomes.
Main Methods
- Analysis of 175 resected stage II/III CRC tumors.
- Histophenotyping of KC using Hematoxylin & Eosin and Masson's trichrome staining.
- Quantitative visual assessment of KC at the invasive margin and statistical survival analysis (Cox regression, Kaplan-Meier, log-rank test).
Main Results
- A KC cutoff of 30% differentiated tumors into Type A (KC ≤ 0.3) and Type B (KC > 0.3).
- Type B stroma (52% of patients) was associated with significantly worse 5-year recurrence-free survival (5-RFS) compared to Type A (48%).
- Increased KC in CRC stroma independently predicted adverse outcomes for 5-RFS (HR = 3.143, p = 0.001).
Conclusions
- Keloid-like collagen (KC) is an independent predictor of 5-year overall and recurrence-free survival in stage II/III CRC patients.
- Higher amounts of KC (>30%) in the tumor stroma are linked to poorer survival rates following surgical treatment.
- KC histophenotyping offers valuable prognostic information for colorectal cancer management.
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