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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
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Association between cathepsins and benign prostate diseases: a bidirectional two-sample Mendelian randomization

Hongliang Cao1, Bin Liu1, Kejian Gong2

  • 1Department of Urology II, The First Hospital of Jilin University, Changchun, China.

Frontiers in Endocrinology
|June 21, 2024
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Summary

This study used Mendelian randomization to explore the genetic link between cathepsins and benign prostate diseases (BPDs). Cathepsin O may protect against benign prostatic hyperplasia (BPH), while cathepsin X is linked to prostatitis.

Keywords:
Mendelian randomizationbenign prostate diseasesbenign prostatic hyperplasia (BPH)bi-directional causal effectscathepsins

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Area of Science:

  • Genetics
  • Urology
  • Biochemistry

Background:

  • Prostate cancer (PCa) research has explored cathepsins, but their role in benign prostate diseases (BPDs) remains understudied.
  • Understanding genetic links between cathepsins and BPDs is crucial for developing new diagnostic and therapeutic strategies.

Purpose of the Study:

  • To investigate the potential causal genetic relationship between cathepsins and benign prostate diseases (BPDs) using Mendelian randomization (MR).
  • To identify specific cathepsins that may influence the risk or progression of BPH and prostatitis.

Main Methods:

  • Utilized summary statistics from FinnGen Biobank for BPH and prostatitis, including over 149,000 individuals.
  • Employed genome-wide association data for ten cathepsins from the IEU OpenGWAS database.
  • Performed five MR analyses, including inverse variance weighted (IVW) and sensitivity analyses, to assess causal effects and rule out pleiotropy.

Main Results:

  • Cathepsin O demonstrated a protective association with benign prostatic hyperplasia (BPH) (IVW OR=0.94).
  • Cathepsin X showed a potential risk association with prostatitis (IVW OR=1.08).
  • Reverse MR indicated prostatitis adversely affects cathepsin V levels (IVW OR=0.89).

Conclusions:

  • This study provides initial genetic evidence linking cathepsins to BPDs.
  • Cathepsin O may be a protective factor for BPH, while cathepsin X is associated with prostatitis risk.
  • Cathepsin V levels are negatively impacted by prostatitis, suggesting potential diagnostic or therapeutic targets for BPDs.