Related Experiment Video

Updated: Jun 23, 2025

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
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Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Published on: June 29, 2013

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Molecular regulators of defective placental and cardiovascular development in fetal growth restriction

Anandita Umapathy1, Alys Clark1,2, Arvind Sehgal3

  • 1Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand.

Clinical Science (London, England : 1979)
|June 21, 2024
PubMed

Insights

Placental insufficiency causes fetal growth restriction (FGR), impacting fetal development and increasing later-life chronic disease risk. Understanding shared placental and heart development factors is crucial for FGR research.

Area of Science:

  • Obstetrics and Gynecology
  • Developmental Biology
  • Cardiovascular Science

Background:

  • Placental insufficiency is a primary cause of fetal growth restriction (FGR).
  • FGR leads to poor fetal growth and increased risks of chronic diseases later in life.
  • Placental and cardiac development are interconnected, suggesting FGR impacts heart development.

Purpose of the Study:

  • To review key molecular factors common to placental and cardiovascular development.
  • To understand their role in FGR and associated developmental defects.

Main Methods:

  • Literature review of growth factors, angiogenic molecules, and transcription factors.
  • Analysis of shared pathways in placental and cardiac development.

Main Results:

  • Identified key molecular players (growth factors, angiogenic molecules, transcription factors) implicated in both placental and cardiac development.
  • Highlighted their common role in FGR pathogenesis.

Conclusions:

  • Shared molecular mechanisms are critical in FGR, affecting both placental function and fetal heart development.
  • Targeting these shared pathways may offer therapeutic strategies for FGR and its long-term consequences.

Keywords:
Fetal growthPlacentaangiogenic factorscardiovascular developmentgrowth factorshomeobox genes

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