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The Case for Neurosurgical Intervention in Cancer Neuroscience.

Joshua D Bernstock^1,2,3, Jakob V E Gerstl¹, Jason A Chen^1,2

¹Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston , Massachusetts , USA.

|June 21, 2024

Summary

Cancer neuroscience reveals how the nervous system impacts cancer growth and how tumors affect the nervous system. This field is clarifying the crucial role of neurosurgery in neuro-oncology.

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Area of Science:

Neuroscience
Oncology
Cancer Biology

Background:

The relationship between the nervous system and cancer is bidirectional, influencing cancer growth and progression.
Cancer cells and the nervous system communicate through direct interactions, paracrine signaling, and neuroimmune pathways.

Purpose of the Study:

To review key mechanisms in cancer neuroscience with neurosurgical relevance.
To outline the future role of neurosurgical interventions in this emerging field.

Main Methods:

Review of recent advances in cancer neuroscience.
Analysis of neurosurgical implications and potential interventions.

Main Results:

Identified direct neuron-cancer interactions at glioma-neuronal synapses.
Highlighted paracrine and neuroimmune mechanisms within the tumor microenvironment.
Emphasized the evolving role of neurosurgery in neuro-oncology.

Conclusions:

Cancer neuroscience offers a new paradigm for understanding and treating brain tumors.
Neurosurgical interventions, including denervation and neuromodulation, show promise in cancer neuroscience.
Further research is needed to fully integrate cancer neuroscience into clinical neuro-oncological care.