Rheumatoid pleural effusion. A transmission and scanning electron microscopic evaluation

Area of Science:

• Rheumatology
• Pathology
• Cell Biology

Background:

• Rheumatoid pleural effusion is uncommon.
• The pathognomonic triad of rheumatoid pleural effusion is rarely observed.
• Previous ultrastructural analysis of this triad is limited.

Observation:

• This paper reports an additional case of rheumatoid pleural effusion exhibiting the pathognomonic triad.
• The case underwent detailed ultrastructural examination.
• Immunochemical characteristics were also analyzed.

Findings:

• The ultrastructural features and immunochemical profile of the effusion were elucidated.
• The study identified round multinucleated inflammatory giant cells, large elongated cells, and granular material.
• Data support that the effusion components originate from pleural rheumatoid nodules.

Implications:

• This research contributes to understanding the pathogenesis of rheumatoid pleural effusions.
• It provides valuable ultrastructural insights into a rare pathological finding.
• The findings may aid in diagnosing and managing rheumatoid arthritis-related pleural disease.