Related Experiment Video
Updated: Jun 23, 2025
A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
Published on: February 7, 2025
COVID-19, MIS-C, and long COVID in pediatric patients: an update
Joshua Rocker1, Caroline Weiss2
1Chief, Division of Pediatric Emergency Medicine, Northwell Health; Cohen Children's Medical Center, New Hyde Park, NY.
Insights
This review covers COVID-19, multisystem inflammatory syndrome in children (MIS-C), and post-acute sequelae of SARS-CoV-2 (PASC). It details their presentation, management, and the latest research on public health, vaccinations, and complications.
Area of Science:
- Infectious Diseases
- Public Health
- Pediatrics
Background:
- COVID-19 (caused by SARS-CoV-2) initially presented as a respiratory illness.
- The long-term effects of SARS-CoV-2, known as post-acute sequelae of SARS-CoV-2 (PASC), impact multiple organ systems.
- Multisystem inflammatory syndrome in children (MIS-C) is a severe condition associated with SARS-CoV-2 infection.
Purpose of the Study:
- To review the clinical presentation, evaluation, and management of COVID-19.
- To discuss the emerging disease entity of MIS-C in children.
- To explore the scope of PASC and its systemic involvement.
Main Methods:
- Literature review of current research on COVID-19, MIS-C, and PASC.
- Analysis of data regarding disease presentation and patient management.
- Synthesis of evidence supporting public health interventions and vaccination strategies.
Main Results:
- COVID-19 affects multiple organ systems beyond the respiratory tract.
- PASC involves widespread organ system sequelae.
- MIS-C presents with significant morbidity and mortality in pediatric populations.
Conclusions:
- Comprehensive understanding and management strategies are crucial for COVID-19, MIS-C, and PASC.
- Public health measures and vaccination remain critical in controlling the pandemic.
- Ongoing research is vital to address the multifaceted impacts of SARS-CoV-2.
Abstract:
COVID-19, the disease caused by SARS-CoV-2, has been disruptive worldwide. It was primarily a respiratory disease that affected many of the medically vulnerable, but the true impact of postacute sequelae of SARS-CoV-2 (PASC), which has been demonstrated to involve all organ systems, is now coming to light. In addition, a new disease entity emerged, multisystem inflammatory syndrome in children (MIS-C), which has had significant morbidity and mortality associated with it. This issue reviews the presentation, evaluation, and management of patients with COVID-19, MIS-C, and PASC. Additionally, the current literature supporting public health measures, as well as COVID-19 vaccinations and their complications are discussed.
More Related Videos
09:03Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic
Published on: November 7, 2020
08:41Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
Related Concept Videos
01:28Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
01:30Pneumonia III: Complications and Assessment
01:28Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...