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Risk Factors for Persistent Staphylococcus aureus Bacteremia in Children
Erin M Thornley1, Robin Alexander2, Jill Popelka1
1From the Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, OH.
The Pediatric Infectious Disease Journal
|June 21, 2024
Summary
Persistent Staphylococcus aureus bacteremia (SAB) in children is linked to faster culture positivity, osteoarticular infections, and elevated inflammatory markers. These factors may predict prolonged SAB in pediatric patients.
Area of Science:
- Pediatric Infectious Diseases
- Bacteriology
- Clinical Microbiology
Background:
- Staphylococcus aureus is a major cause of pediatric bacteremia.
- Persistent S. aureus bacteremia (SAB) is associated with worse outcomes in children.
- Factors contributing to persistent SAB in children are not well understood.
Purpose of the Study:
- To identify risk factors for the development of persistent S. aureus bacteremia in pediatric patients.
- To analyze clinical and laboratory data associated with persistent SAB.
Main Methods:
- Retrospective analysis of a prospective observational study.
- Involved pediatric patients hospitalized with S. aureus infection over 3.5 years.
- Compared characteristics of patients with and without persistent SAB.
Main Results:
- 43% of children with SAB developed persistent bacteremia.
- Persistent SAB was associated with shorter time to culture positivity (median 16 vs. 20 hours).
- Osteoarticular infection (93%) and higher inflammatory markers (ESR, CRP) were more common in persistent SAB.
Conclusions:
- Shorter time to culture positivity is a potential risk factor for persistent SAB.
- Osteoarticular infection is strongly associated with persistent SAB in children.
- Elevated inflammatory markers may indicate increased risk for persistent S. aureus bacteremia.
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