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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
Blood Transfusion01:15

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...

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Related Experiment Video

Updated: May 15, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Complex delayed blood transfusion reaction: A case report.

Qiang Li1, Jinhui Xie2, Jiali Sun1

  • 1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

Medicine
|June 21, 2024
PubMed
Summary
This summary is machine-generated.

Identifying multiple alloantibodies is crucial for resolving ineffective blood transfusions. This case study demonstrates how strategic interventions based on alloantibody identification improve patient outcomes and reduce healthcare costs.

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Area of Science:

  • Transfusion Medicine
  • Immunology
  • Hematology

Background:

  • Ineffective blood transfusions lead to significant blood resource wastage and increased medical expenses.
  • Identifying multiple alloantibodies is critical for overcoming transfusion challenges.

Purpose of the Study:

  • To analyze a case of ineffective clinical transfusion.
  • To highlight the significance of identifying multiple alloantibodies in resolving transfusion challenges.

Main Methods:

  • Detailed follow-up of a patient's treatment journey.
  • Utilized various methodologies for identifying multiple alloantibodies.
  • Implemented a strategic intervention based on findings.

Main Results:

  • Successful patient outcome achieved post-intervention.
  • Demonstrated the critical role of alloantibody identification in addressing transfusion problems.

Conclusions:

  • Thorough analysis of ineffective transfusions is essential.
  • Scientifically formulated transfusion plans improve hemoglobin levels and patient outcomes.
  • Optimized transfusion strategies reduce blood wastage and medical costs.