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Updated: Jun 23, 2025

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography
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Bluish veil detection and lesion classification using custom deep learnable layers with explainable artificial

M A Rasel1, Sameem Abdul Kareem1, Zhenli Kwan2

  • 1Department of Artificial Intelligence, Faculty of Computer Science and Information Technology, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.

Computers in Biology and Medicine
|June 21, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces a novel Deep Convolutional Neural Network (DCNN) for detecting the blue-white veil (BWV) in skin lesions, a key indicator of melanoma. The DCNN significantly improves early melanoma diagnosis accuracy.

Keywords:
Bluish veilDCNNDermoscopic imageLIMEMelanoma

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Area of Science:

  • Dermatology and Artificial Intelligence
  • Medical Imaging Analysis
  • Oncology

Background:

  • Melanoma is a deadly skin cancer with thousands of global fatalities.
  • The blue-white veil (BWV) is a critical diagnostic feature for melanoma.
  • Limited research exists on automated BWV detection in dermatological images.

Purpose of the Study:

  • To develop and evaluate a Deep Convolutional Neural Network (DCNN) for accurate BWV detection in skin lesions.
  • To improve early melanoma diagnosis through enhanced BWV identification.
  • To utilize explainable artificial intelligence (XAI) for model interpretability.

Main Methods:

  • A non-annotated dataset was converted to an annotated one using a novel imaging algorithm with color threshold techniques.
  • A DCNN was designed with custom layers and trained on individual and combined dermoscopic datasets.
  • An explainable artificial intelligence (XAI) algorithm was applied to interpret the DCNN's decision-making process.

Main Results:

  • The proposed DCNN achieved high testing accuracies: 85.71% (PH2), 95.00% (ISIC), 95.05% (combined), and 90.00% (Derm7pt).
  • The DCNN outperformed conventional BWV detection models across various datasets.
  • The integration of XAI provided insights into the DCNN's BWV detection mechanism.

Conclusions:

  • The developed DCNN coupled with XAI significantly enhances BWV detection in skin lesions.
  • This approach offers a robust tool for improving early melanoma diagnosis.
  • The study highlights the potential of AI in dermatological image analysis for cancer detection.