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Surface nanocoating-based universal platform for programmed delivery of microorganisms in complicated digestive tract
Yajing Du1, Hao Lin Guo2, Xin Su1
1School of Life Sciences, Tianjin University, Tianjin 300072, China.
Journal of Colloid and Interface Science
|June 21, 2024
Summary
A novel surface nanocoating-based universal platform (SNUP) enables targeted delivery and colonization of therapeutic microbes in the gut. This microbial therapy approach successfully treated Parkinson
Area of Science:
- Biotechnology and Biomedical Engineering
- Microbiology and Immunology
- Gastroenterology and Hepatology
Background:
- Microbial therapies offer potential for treating diverse diseases.
- Effective colonization of therapeutic microbes in the complex intestinal environment is a major hurdle.
- Current methods often require specific targeting molecules, limiting universality.
Purpose of the Study:
- To develop a universal platform for controlled release and targeted colonization of therapeutic microbes in the digestive tract.
- To overcome challenges associated with microbial delivery in the complex intestinal system without targeting molecules.
- To demonstrate the efficacy of this platform in a disease model.
Main Methods:
- Development of a surface nanocoating-based universal platform (SNUP) for microbial encapsulation.
- Regulation of SNUP decomposition by modifying surface layers and sequences for controlled release in the gut.
- Encapsulation of Liiliilactobacillus salivarius (LS@CCMC) with SNUP and evaluation in a mouse model of Parkinson's disease.
Main Results:
- SNUP enabled controlled release and targeted colonization of therapeutic microbes in specific intestinal regions (small intestine and colon).
- SNUP protected microbial bioactivity from degradation by stomach acid and digestive enzymes.
- SNUP-encapsulated LS@CCMC efficiently colonized the small intestine and significantly ameliorated Parkinson's disease symptoms in mice, linked to sustained gamma-aminobutyric acid (GABA) secretion.
Conclusions:
- The SNUP technology provides a simple, universal method for colonized microbial therapy, eliminating the need for specific targeting molecules.
- This platform facilitates targeted theranostics, precision medicine, and personalized medicine applications.
- SNUP represents a significant advancement in delivering therapeutic microbes for treating complex diseases.
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