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A metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance

Randall T Mertens1, Aditya Misra2, Peng Xiao3

  • 1Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital, and Harvard Medical School, Boston, MA 02115, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.

Immunity
|June 21, 2024
PubMed

Keywords:
IL-18SLC12A3bistable circuitcGAMPfatty acid oxidationimmunometabolismintestinal tolerancemacrophagemetabolic reprogrammingmetabolic switch

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