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Understanding Breathlessness Burden and Psychophysiological Correlates in Asthma.
Hayley Lewthwaite1, Peter G Gibson2, Paola D Urroz Guerrero1
1Centre for Research Excellence in Treatable Traits, College of Health, Medicine, and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Over half of severe asthma patients experience physically limiting breathlessness. Targeting psychophysiological factors like BMI and hyperventilation may offer relief for this common, distressing asthma symptom.
Area of Science:
- Pulmonary Medicine
- Respiratory Health
- Asthma Research
Background:
- Breathlessness is a complex, often under-recognized symptom in asthma.
- Its burden is significant, impacting quality of life for many asthma patients.
Purpose of the Study:
- To compare the prevalence of breathlessness in severe asthma versus mild-to-moderate asthma.
- To identify psychophysiological factors associated with breathlessness in asthma patients.
Main Methods:
- Cross-sectional study involving 144 participants with mild-to-severe asthma.
- Multidimensional assessment including modified Medical Research Council (mMRC) dyspnea score and Dyspnoea-12.
- Multivariate logistic regression used to identify predictors of breathlessness.
Main Results:
- 53% of severe asthma patients reported physically limiting breathlessness (mMRC ≥2) compared to 31% with mild-to-moderate asthma.
- Higher Dyspnoea-12 scores were observed in the severe asthma group.
- Significant predictors of breathlessness included BMI, asthma control, exercise capacity, and hyperventilation symptoms.
Conclusions:
- Physically limiting breathlessness affects over half of severe asthma patients, even with treatment.
- Addressing psychophysiological factors is a potential strategy for managing breathlessness in asthma.
- Relieving breathlessness is a high priority for individuals with asthma.
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