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Updated: Jun 23, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
Metabolic reprogramming in tumor immune microenvironment: Impact on immune cell function and therapeutic implications
Yuqiang Liu1, Yu Zhao2, Huisheng Song3
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Thoracic Surgery and Oncology, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.
Cancer cells reprogram metabolism for growth, impacting the tumor microenvironment (TME). Targeting these metabolic shifts offers novel therapeutic strategies for cancer treatment.
Area of Science:
- Oncology
- Cancer Metabolism
- Tumor Microenvironment (TME)
Background:
- Metabolic reprogramming is crucial for tumor progression and cancer cell adaptation.
- Cancer cells exhibit altered metabolism of glucose, amino acids, and lipids to meet high energy demands.
- These metabolic changes influence both tumor cell proliferation and the TME.
Purpose of the Study:
- To review aberrant metabolic pathways in cancer cells within the TME.
- To explore the reprogramming of immune cells in the TME.
- To discuss therapeutic strategies targeting metabolic alterations.
Main Methods:
- Literature review of metabolic reprogramming in cancer.
- Analysis of metabolic shifts in glucose, amino acid, and lipid metabolism.
- Examination of immune cell reprogramming within the TME.
Main Results:
- Cancer cells exhibit distinct metabolic pathways compared to normal cells.
- Metabolic reprogramming affects tumor cell proliferation and TME dynamics.
- Immune cells within the TME also undergo metabolic reprogramming.
Conclusions:
- Targeting cancer cell metabolism is a promising therapeutic strategy.
- Modulating nutrient metabolism and the TME can enhance anti-tumor immune responses.
- Metabolic reprogramming offers fresh perspectives for innovative cancer treatments.
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