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Updated: Jun 23, 2025

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Factor XI inhibition in hemodialysis patients: the safer anticoagulation?

Eleni Stamellou1, Heidi Noels2, Jürgen Floege3

  • 1Department of Nephrology, School of Medicine, University of Ioannina, Ioannina, Greece; Division of Nephrology and Rheumatology, Rheinisch Westfälische Technische Hochschule (RWTH) University of Aachen, Aachen, Germany.

Kidney International
|June 21, 2024
PubMed

Chronic hemodialysis patients exhibit an excessive cardiovascular risk and a marked increase in both thromboembolism and bleeding episodes. Factor XI inhibition may provide anticoagulation, with a low risk of bleeding, and several factor XI inhibitors, including fesomersen, an antisense oligonucleotide, are under development. Recently, a phase 2 study of fesomersen showed a good safety profile in chronic hemodialysis patients and suggested that clotting rates of the arteriovenous fistula and the dialysis circuit are lower.

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