Using a smartphone-based self-management platform to study sex differences in Parkinson's disease: multicenter,...

Area of Science:

• Neurology
• Digital Health
• Patient-Reported Outcomes

Background:

• Patient-reported outcomes (PROs) are crucial for understanding clinical characteristics.
• Remote PRO measurement is a recent advancement in healthcare.
• Sex differences in Parkinson's disease (PD) PROs remain under-researched.

Purpose of the Study:

• To investigate sex differences in PROs among Parkinson's disease patients.
• To evaluate the utility of a smartphone-based platform for remote PRO data collection.

Main Methods:

• A smartphone-based self-management platform was utilized for remote PRO measurement.
• 1828 Parkinson's disease patients (1001 male, 827 female) completed PRO submissions.
• Data analysis focused on identifying statistically significant sex-based variations in reported outcomes.

Main Results:

• Significant sex differences in PROs were observed.
• Females had lower height, weight, and BMI than males.
• Females reported higher rates of depression and dyskinesia; males reported more hyposmia and daytime sleepiness.

Conclusions:

• The study provides evidence of distinct sex differences in PD patient-reported outcomes.
• These findings underscore the importance of considering gender in clinical decision-making for PD.
• Remote PRO measurement via smartphone platforms is feasible and effective for PD patients.