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Related Experiment Video

Updated: May 2, 2026

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
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Thymic Rosai-Dorfmann disease: a case report.

Gaohua Liu1, Min Jing2, Juan Wang3

  • 1Department of Cardiothoracic Surgery, The First People's Hospital of Neijiang, Sichuan, 641000, China.

Journal of Cardiothoracic Surgery
|June 21, 2024
PubMed
Summary

Rosai-Dorfman disease (RDD) rarely affects the thymus. Surgical removal of a thymic RDD lesion resulted in a complete cure, with no recurrence after three years of follow-up.

Keywords:
DiagnoseRosai–Dorfman disease (RDD)SurgeryThymus

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Area of Science:

  • Thoracic Surgery
  • Pathology
  • Oncology

Background:

  • Rosai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy, typically affects lymph nodes but can occur extranodally.
  • Extranodal RDD is seen in about 40% of cases, with thymic involvement being exceptionally rare.

Observation:

  • A 52-year-old male presented with an incidental 7x6 cm anterior mediastinal mass detected via chest CT.
  • Surgical resection of the mediastinal lesion revealed Rosai-Dorfman disease originating from the thymus.

Findings:

  • Postoperative pathology confirmed RDD of thymic origin.
  • The patient experienced no recurrence after 3 years of telephone follow-up, indicating a successful surgical outcome.

Implications:

  • Thymic Rosai-Dorfman disease is challenging to diagnose preoperatively via CT, often being mistaken for common mediastinal tumors.
  • Increased awareness of this rare thymic manifestation of RDD is crucial for accurate diagnosis and management.
  • Surgical resection appears to be an effective treatment for thymic RDD, leading to favorable long-term outcomes.