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Diffuse hyperpigmentation with guttate hypopigmentation: a new pigmentary disorder.
Li-Wen Zhang1, Juan Wu2, Cong-Hui Li1
1Department of Dermatovenereology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.
European Journal of Dermatology : EJD
|June 22, 2024
Summary
Diffuse hyperpigmentation with guttate hypopigmentation (DHGH) is a newly identified skin condition. This study reviews nine cases, detailing its clinical, dermoscopic, and histopathological features to aid recognition and management.
Area of Science:
- Dermatology
- Pigmentary Disorders
- Dermopathology
Background:
- Diffuse hyperpigmentation with guttate hypopigmentation (DHGH) is an acquired pigmentary disorder.
- Limited case reports exist, primarily in the Chinese population.
- Improved recognition and management are needed.
Purpose of the Study:
- To summarize clinical, dermoscopic, and histopathological findings of DHGH.
- To enhance understanding and identification of this rare condition.
- To facilitate better patient management strategies.
Main Methods:
- Retrospective analysis of nine DHGH cases.
- Detailed review of clinical presentations.
- Dermoscopic and histopathological examination of lesions.
Main Results:
- Nine female patients, aged 6-24 years, presented with generalized lesions.
- Typical lesions: uniform hypopigmented spots (2-5 mm) on diffuse hyperpigmentation.
- Dermoscopy showed blurred pigmentation, vascular changes, and perifollicular findings; histopathology revealed epidermal pigment abnormalities and dermal inflammation.
Conclusions:
- DHGH is a distinct entity with unique clinical features.
- It has predominantly been reported in the Chinese population.
- Further research into etiology and pathogenesis is warranted.
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