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Pigmentation01:19

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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Related Experiment Video

Updated: Jun 23, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Diffuse hyperpigmentation with guttate hypopigmentation: a new pigmentary disorder.

Li-Wen Zhang1, Juan Wu2, Cong-Hui Li1

  • 1Department of Dermatovenereology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.

European Journal of Dermatology : EJD
|June 22, 2024
PubMed
Summary

Diffuse hyperpigmentation with guttate hypopigmentation (DHGH) is a newly identified skin condition. This study reviews nine cases, detailing its clinical, dermoscopic, and histopathological features to aid recognition and management.

Keywords:
diffuse hyperpigmentationguttate hypopigmentationidiopathic guttate hypomelanosisnew entitypigmentary disorder

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Quantification of Hypopigmentation Activity In Vitro
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Area of Science:

  • Dermatology
  • Pigmentary Disorders
  • Dermopathology

Background:

  • Diffuse hyperpigmentation with guttate hypopigmentation (DHGH) is an acquired pigmentary disorder.
  • Limited case reports exist, primarily in the Chinese population.
  • Improved recognition and management are needed.

Purpose of the Study:

  • To summarize clinical, dermoscopic, and histopathological findings of DHGH.
  • To enhance understanding and identification of this rare condition.
  • To facilitate better patient management strategies.

Main Methods:

  • Retrospective analysis of nine DHGH cases.
  • Detailed review of clinical presentations.
  • Dermoscopic and histopathological examination of lesions.

Main Results:

  • Nine female patients, aged 6-24 years, presented with generalized lesions.
  • Typical lesions: uniform hypopigmented spots (2-5 mm) on diffuse hyperpigmentation.
  • Dermoscopy showed blurred pigmentation, vascular changes, and perifollicular findings; histopathology revealed epidermal pigment abnormalities and dermal inflammation.

Conclusions:

  • DHGH is a distinct entity with unique clinical features.
  • It has predominantly been reported in the Chinese population.
  • Further research into etiology and pathogenesis is warranted.