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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Jun 23, 2025

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
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Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

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A comprehensive supportive care program for fine-tuning cancer immunotherapy.

Alexandre Tayart de Borms1, Julien Colard-Thomas1, Pierre-Ivan Laurent2

  • 1Department of Medical Oncology, Montpellier Cancer Institute (ICM), 34090, Montpellier, France.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
|June 22, 2024
PubMed
Summary

Supportive care, including diet, exercise, ePROs, and medication management, can improve cancer immunotherapy response and reduce side effects. Further clinical trials are needed to confirm the benefits of this multimodal approach.

Keywords:
Co-medicationsDietElectronic patient-reported outcomesImmune checkpoint inhibitorImmunotherapyPhysical activitySupportive care

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Area of Science:

  • Oncology
  • Immunotherapy
  • Supportive Care

Background:

  • Supportive care is a crucial component of modern oncology.
  • Research is focusing on optimizing immunotherapy with immune checkpoint inhibitors (ICIs).

Purpose of the Study:

  • To explore how supportive care strategies can enhance cancer immunotherapy efficacy.
  • To identify methods for minimizing adverse effects associated with ICIs.

Main Methods:

  • Investigating four key areas: diet, physical activity, electronic patient-reported outcomes (ePRO), and co-medication management.
  • Proposing a systematic multimodal supportive care program for patients on ICIs.

Main Results:

  • Diet and physical activity can modulate the immune system and microbiota.
  • ePROs enable early detection and treatment of immune-related adverse events.
  • Co-medication management can mitigate negative impacts on ICI efficacy.

Conclusions:

  • A multimodal supportive care program integrating nutritional counseling, supervised physical activity, ePRO monitoring, and pharmaceutical counseling may benefit patients receiving ICIs.
  • This integrated approach requires validation through rigorous randomized clinical trials.