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Comprehensive HLA Typing from a Current Allele Database Using Next-Generation Sequencing Data

Shuji Kawaguchi¹, Koichiro Higasa¹, Ryo Yamada¹

¹Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Methods in Molecular Biology (Clifton, N.J.)

|June 22, 2024

Abstract:

HLA allele information is essential for a variety of medical applications, such as genomic studies of multifactorial diseases, including immune system and inflammation-related disorders, and donor selection in organ transplantation and regenerative medicine. To obtain this information, an accurate HLA typing method that is applicable for any allele registered in HLA allele databases is needed. Here we describe a method-called HLA-HD-for determining alleles from a current HLA database using next-generation sequencing (NGS) results.

Keywords:

Bioinformatics Database HLA typing HLA-HD NGS Software

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