[Seronegative autoimmune hepatitis].

Area of Science:

• Hepatology
• Immunology
• Internal Medicine

Background:

• Autoimmune hepatitis (AIH) is a rare, chronic liver disease of unknown etiology.
• It predominantly affects women and presents with varying severity, from asymptomatic to acute liver failure.
• Diagnosis typically involves autoantibody detection (ANA, ASMA, anti-LKM), but 10% of cases are seronegative, necessitating liver biopsy.

Purpose of the Study:

• To conduct a bibliographic review of autoimmune hepatitis.
• To consolidate current understanding and management strategies for AIH.
• To address the limited evidence and varying recommendations for AIH diagnosis and treatment.

Main Methods:

• Bibliographic review of existing literature on autoimmune hepatitis.
• Analysis of diagnostic criteria, including autoantibody testing and liver biopsy indications.
• Synthesis of information regarding clinical presentation and disease progression.

Main Results:

• AIH diagnosis relies on autoantibodies, but seronegative AIH requires liver biopsy.
• Clinical presentation of AIH is highly variable.
• Limited evidence necessitates clear guidelines for AIH management.

Conclusions:

• A comprehensive understanding of AIH is crucial for effective management.
• Further research is needed to clarify diagnostic and therapeutic guidelines.
• This review provides essential information for clinicians managing AIH patients.