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Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
09:35

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Published on: February 1, 2017

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Screening for viral hepatitis carriage

Jie Tang1, Hong Zhao2, Yi-Hua Zhou3

  • 1Department of Obstetrics and Gynecology, Wujin Hospital Affiliated with Jiangsu University, Jiangsu, China; Department of Obstetrics and Gynecology, The Wujin Clinical College of Xuzhou Medical University, Jiangsu, China.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|June 22, 2024
PubMed

Insights

This review covers viral hepatitis in pregnancy, focusing on screening, preventing mother-to-child transmission of hepatitis B and C, and managing hepatitis A, B, C, and E. Key strategies include timely infant vaccination and maternal antiviral therapy.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Maternal-Fetal Medicine

Background:

  • Viral hepatitis poses a significant global health challenge during pregnancy.
  • Hepatitis A, B, C, and E are common viral infections affecting pregnant individuals worldwide.

Purpose of the Study:

  • To review antenatal screening protocols for hepatitis A, B, C, and E.
  • To outline strategies for preventing mother-to-child transmission (MTCT) of hepatitis B and C.
  • To discuss the management of hepatitis A, B, C, and E in pregnant women.

Main Methods:

  • Review of current literature on viral hepatitis in pregnancy.
  • Analysis of established guidelines for screening and management.
  • Evaluation of prevention strategies for MTCT.

Main Results:

  • Timely neonatal administration of hepatitis B immunoglobulin and vaccine is crucial for preventing HBV MTCT.
  • Perinatal antiviral prophylaxis (tenofovir disoproxil fumarate) further reduces HBV MTCT in high-viral-load mothers.
  • Risk-avoidance during labor/delivery for HCV-infected mothers may reduce HCV MTCT.
  • Regular liver function tests are critical for early detection of hepatic injury or liver failure.

Conclusions:

  • Comprehensive antenatal screening and targeted interventions are essential for managing viral hepatitis in pregnancy.
  • Effective prevention of MTCT for hepatitis B and C can be achieved through vaccination, antiviral therapy, and careful delivery management.
  • Prompt recognition and management of hepatic complications are vital to prevent maternal mortality.

Keywords:
ImmunoprophylaxisLiver failureMother-to-child transmission (MTCT)Perinatal antiviral prophylaxis (PAP)Viral hepatitis

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