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Related Concept Videos

Hepatitis01:25

Hepatitis

99
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
99
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

28
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
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Related Experiment Video

Updated: May 5, 2026

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
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Screening for viral hepatitis carriage.

Jie Tang1, Hong Zhao2, Yi-Hua Zhou3

  • 1Department of Obstetrics and Gynecology, Wujin Hospital Affiliated with Jiangsu University, Jiangsu, China; Department of Obstetrics and Gynecology, The Wujin Clinical College of Xuzhou Medical University, Jiangsu, China.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|June 22, 2024
PubMed
Summary
This summary is machine-generated.

This review covers viral hepatitis in pregnancy, focusing on screening, preventing mother-to-child transmission of hepatitis B and C, and managing hepatitis A, B, C, and E. Key strategies include timely infant vaccination and maternal antiviral therapy.

Keywords:
ImmunoprophylaxisLiver failureMother-to-child transmission (MTCT)Perinatal antiviral prophylaxis (PAP)Viral hepatitis

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Maternal-Fetal Medicine

Background:

  • Viral hepatitis poses a significant global health challenge during pregnancy.
  • Hepatitis A, B, C, and E are common viral infections affecting pregnant individuals worldwide.

Purpose of the Study:

  • To review antenatal screening protocols for hepatitis A, B, C, and E.
  • To outline strategies for preventing mother-to-child transmission (MTCT) of hepatitis B and C.
  • To discuss the management of hepatitis A, B, C, and E in pregnant women.

Main Methods:

  • Review of current literature on viral hepatitis in pregnancy.
  • Analysis of established guidelines for screening and management.
  • Evaluation of prevention strategies for MTCT.

Main Results:

  • Timely neonatal administration of hepatitis B immunoglobulin and vaccine is crucial for preventing HBV MTCT.
  • Perinatal antiviral prophylaxis (tenofovir disoproxil fumarate) further reduces HBV MTCT in high-viral-load mothers.
  • Risk-avoidance during labor/delivery for HCV-infected mothers may reduce HCV MTCT.
  • Regular liver function tests are critical for early detection of hepatic injury or liver failure.

Conclusions:

  • Comprehensive antenatal screening and targeted interventions are essential for managing viral hepatitis in pregnancy.
  • Effective prevention of MTCT for hepatitis B and C can be achieved through vaccination, antiviral therapy, and careful delivery management.
  • Prompt recognition and management of hepatic complications are vital to prevent maternal mortality.