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Nomogram based on immune-inflammatory indicators and age-adjusted charlson comorbidity index score to predict prognosis of postoperative parotid gland carcinoma patients

  • 0Department of Radiotherapy Oncology, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, Xinxiang, Henan, 453100, Henan, China.
Bmc Oral Health +

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June 22, 2024

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June 22, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

This study developed nomogram models to predict prognosis for parotid gland carcinoma (PGC) patients, incorporating immune-inflammatory-nutrition indicators and age-adjusted Charlson comorbidity index score (ACCI). These models offer individualized prognostic references for better patient follow-up strategies.

Area Of Science

  • Oncology
  • Surgical Oncology
  • Cancer Prognostics

Background

  • Parotid gland carcinoma (PGC) is a rare malignancy.
  • Identifying reliable prognostic factors is crucial for PGC patient management.

Purpose Of The Study

  • To investigate the prognostic role of immune-inflammatory-nutrition indicators and ACCI in PGC.
  • To develop and validate nomogram models for predicting disease-free survival (DFS) and overall survival (OS) in PGC patients.

Main Methods

  • Retrospective analysis of 344 PGC patients treated with surgical resection.
  • Univariate and multivariate Cox regression to identify independent prognostic factors.
  • Development and validation of nomogram models for DFS and OS prediction.

Main Results

  • AJCC stage, pathology, tumor location, ENE, SII, PNI, ACCI, and GPS were independent prognostic factors for DFS and OS.
  • Nomogram models demonstrated good discriminative capability (AUCs > 0.8) and clinical utility.
  • The new risk stratification system showed superior discrimination compared to the AJCC stage system.

Conclusions

  • Immune-inflammatory-nutrition indicators and ACCI are significant prognostic factors for PGC.
  • The developed nomograms provide individualized prognostic references for PGC patients.
  • Adjuvant radiotherapy showed no benefit in the low-risk subgroup post-surgery.

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