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The causal relationship and potential mediators between plasma lipids and atopic dermatitis: a bidirectional
Yuke Zhang1, Bohan Zhang1, Ru Wang1
1Department of Plastic and Burn Surgery, West China Hospital, Sichuan University, No.37, Guoxue Alley, Chengdu, Sichuan, 610041, China.
Certain plasma lipids causally influence atopic dermatitis risk, with some acting via inflammatory proteins like IL-18R1. Targeting lipid profiles may offer a novel therapeutic strategy for atopic dermatitis.
Area of Science:
- Genetics
- Immunology
- Metabolomics
Background:
- Observational studies suggest altered plasma lipid profiles in atopic dermatitis patients.
- Causal links between lipid profiles and atopic dermatitis remain unclear.
- Investigating the role of circulating inflammatory proteins as mediators is crucial.
Purpose of the Study:
- To explore causal relationships between 179 plasma lipid species and atopic dermatitis.
- To determine if circulating inflammatory proteins mediate these effects.
- To identify potential therapeutic targets for atopic dermatitis.
Main Methods:
- Bidirectional two-sample, two-step Mendelian randomization study using public GWAS data.
- Inverse variance-weighted (IVW) method as primary analysis.
- MR-Egger, weighted median, MR-PRESSO, and Cochran's Q tests for sensitivity analyses.
Main Results:
- Specific phosphatidylcholine (PC) and triacylglycerol (TAG) species showed inverse or positive correlations with atopic dermatitis risk.
- Atopic dermatitis did not significantly influence plasma lipid species.
- Interleukin-18 receptor 1 (IL-18R1) was identified as a mediator for PC (18:1_20:2) and atopic dermatitis risk.
Conclusions:
- Plasma lipids may contribute to atopic dermatitis pathogenesis by affecting inflammatory proteins.
- Modulating plasma lipid levels presents a potential novel therapeutic avenue for atopic dermatitis.
- Further research into lipid-protein interactions in atopic dermatitis is warranted.
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