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Bioinformatics analysis of potential common pathogenic mechanisms for COVID-19 and venous thromboembolism

Ling Zhang1, Jing Qin1, Peiwu Li1

  • 1Department of Emergency Medicine, Lanzhou University Second Hospital, Lanzhou, Gansu, China.

Cytokine
|June 23, 2024
PubMed

Insights

Patients with coronavirus disease 2019 (COVID-19) face higher venous thromboembolism (VTE) risks. This study identified common molecular pathways and eight key genes, offering insights into VTE and COVID-19 pathogenesis.

Area of Science:

  • Molecular biology
  • Genomics
  • Bioinformatics

Background:

  • Coronavirus disease 2019 (COVID-19) patients exhibit elevated venous thromboembolism (VTE) rates.
  • The precise molecular mechanisms linking COVID-19 and VTE remain unclear.
  • Further investigation into these molecular underpinnings is crucial.

Purpose of the Study:

  • To elucidate the molecular mechanisms shared between COVID-19 and VTE.
  • To identify common differentially expressed genes (DEGs) and regulatory networks.
  • To explore potential diagnostic markers for both conditions.

Main Methods:

  • Downloaded and analyzed gene expression profiles for COVID-19 and VTE from the GEO database.
  • Identified common DEGs, performed functional annotation, and constructed protein-protein interaction (PPI) networks.
  • Built transcription factor (TF)-gene and TF-miRNA regulatory networks for hub genes.

Main Results:

  • Identified 42 common DEGs between COVID-19 and VTE.
  • Functional analyses revealed shared biological functions and signaling pathways.
  • Discovered 8 significant hub genes (RSL24D1, RPS17, RPS27, HINT1, COX7C, RPL35, RPL34, NDUFA4) with diagnostic potential.

Conclusions:

  • The study highlights common pathogenic pathways in COVID-19 and VTE.
  • Identified pivotal genes may serve as novel targets for mechanistic research.
  • Findings offer new perspectives for understanding and potentially treating these interconnected conditions.
Abstract

Keywords:
Bioinformatics analysisCOVID-19Pathogenic mechanismsVTE

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