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Updated: Jun 23, 2025
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
249
Colorectal cancer
Cathy Eng1, Takayuki Yoshino2, Erika Ruíz-García3
1Division of Hematology and Oncology, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Lancet (London, England)
|June 23, 2024
Summary
Colorectal cancer incidence is rising globally, especially in younger patients. Advances in systemic therapy, surgery, and targeted treatments are improving survival rates for this common cancer.
Area of Science:
- Oncology
- Gastroenterology
- Surgical Oncology
Background:
- Colorectal cancer remains a leading global cancer diagnosis, with rising incidence in emerging economies and increasing concern for early-onset cases (age ≤50 years).
- Despite decreasing rates in some high-income populations, the overall global burden necessitates continued research and clinical advancements.
Purpose of the Study:
- To provide a multidisciplinary overview of recent clinical advances in the management of colorectal cancer.
- To highlight key areas of ongoing research and future directions in colorectal cancer treatment.
Main Methods:
- This overview synthesizes current clinical research and expert perspectives on colorectal cancer management.
- It examines advances in systemic therapy, surgical techniques, and molecularly targeted treatments.
Main Results:
- Significant progress has been made in increasing overall survival rates through improved systemic therapies and surgical options.
- Ongoing research focuses on sphincter preservation, precision oncology, circulating tumor DNA, microbiome analysis, and liver metastases management.
Conclusions:
- Multidisciplinary approaches and ongoing research are crucial for improving outcomes in colorectal cancer.
- Future directions emphasize personalized medicine and innovative locoregional strategies to combat this disease.
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