Related Experiment Video

Updated: Jun 23, 2025

Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
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Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess

Published on: June 1, 2022

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Permeabilization of the outer mitochondrial membrane: Mechanisms and consequences

Maria A Yapryntseva1, Boris Zhivotovsky2, Vladimir Gogvadze3

  • 1Engelhardt Institute of Molecular Biology, RAS, 119991 Moscow, Russia; Faculty of Medicine, Lomonosov Moscow State University, 119192 Moscow, Russia.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|June 23, 2024
PubMed

Insights

Mitochondrial outer membrane permeabilization is a key process in cell death, regulating molecule passage and cell fate. This review details pore types, activation mechanisms, and disease relevance.

Area of Science:

  • Cell Biology
  • Biochemistry
  • Pathology

Background:

  • The outer mitochondrial membrane (OMM) regulates cellular processes, including energy production and cell death.
  • OMM permeabilization allows passage of small molecules and is critical for various cell death pathways.
  • Dysregulation of OMM permeabilization is implicated in numerous diseases.

Purpose of the Study:

  • To provide a comprehensive review of outer mitochondrial membrane permeabilization.
  • To discuss the distinct types of pores, their activation mechanisms, and physiological/pathological roles.
  • To explore the involvement of OMM permeabilization in various disease states.

Main Methods:

  • Literature review of scientific articles on mitochondrial outer membrane permeabilization.
  • Analysis of mechanisms underlying pore formation and activation.
  • Synthesis of information on the role of OMM permeabilization in different diseases.

Main Results:

  • Identified distinct pore types in the OMM, each activated by specific stimuli.
  • Elucidated diverse mechanisms controlling OMM permeabilization.
  • Highlighted the critical role of OMM permeabilization in autophagy, apoptosis, and necroptosis.
  • Demonstrated the involvement of OMM permeabilization in the pathogenesis of various diseases.

Conclusions:

  • OMM permeabilization is a tightly regulated process with significant physiological and pathological implications.
  • Understanding OMM permeabilization mechanisms offers therapeutic targets for diseases involving cell death pathways.
  • Further research into OMM permeabilization is crucial for advancing disease treatment strategies.
Keywords:
Cell deathDiseaseMechanismsMitochondrial membranePermeabilization

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