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Total Synthesis of (+)-Silybin A

Makoto Inai1, Hiroto Sagara1, Yoshinori Ueno1

  • 1School of Pharmaceutical Sciences, University of Shizuoka.

Chemical & Pharmaceutical Bulletin
|June 23, 2024
PubMed

Keywords:
hybrid polyphenolmodified Julia–Kocienski olefinationquinomethidesilybin Atotal synthesis

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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
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