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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Jun 23, 2025

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells
08:46

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells

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Recent Advances in CAR-T Therapy.

Meher Binte Ali1

  • 1University of Maryland Medical Center, Baltimore, MD, USA.

Cancer Control : Journal of the Moffitt Cancer Center
|June 24, 2024
PubMed
Summary

Chimeric antigen receptor (CAR) T-cell therapy offers a novel treatment for refractory hematological cancers by reprogramming a patient's immune cells. This review covers CAR-T manufacturing, side effects, and the emerging risk of secondary T-cell malignancies.

Keywords:
CAR-T therapycytokine release syndromelymphomaneurotoxicity

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Area of Science:

  • Immunotherapy
  • Oncology
  • Cellular Therapy

Background:

  • Chimeric antigen receptor (CAR) T-cell therapy represents a significant advancement in treating hematological malignancies resistant to conventional treatments.
  • This immunotherapy approach involves genetically modifying a patient's T cells to target and eliminate cancer cells.

Discussion:

  • Manufacturing processes for CAR-T cells are complex and critical for therapeutic efficacy.
  • Common adverse events associated with CAR-T therapy require careful management.
  • An emerging concern is the potential risk of developing secondary T-cell malignancies following treatment.

Key Insights:

  • CAR-T cell therapy is a potent immunotherapy for refractory hematological cancers.
  • Understanding the manufacturing process is key to successful CAR-T cell therapy.
  • Monitoring for and managing side effects, including secondary malignancies, is crucial.

Outlook:

  • Further research into optimizing CAR-T cell manufacturing and safety profiles is warranted.
  • Long-term surveillance for potential adverse events, such as T-cell malignancies, is essential.
  • Continued development aims to broaden the application and improve the safety of CAR-T cell therapies.