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Ionic Liquid-Based Silane for SiO2 Nanoparticles: A Versatile Coupling Agent for Dental Resins
Isadora Martini Garcia1,2, Virgínia Serra de Souza3, Abdulrahman A Balhaddad4
1Division of Cariology and Operative Dentistry, Department of Comprehensive Dentistry, University of Maryland School of Dentistry, Baltimore, Maryland 21201, United States.
ACS Applied Materials & Interfaces
|June 24, 2024
Summary
Researchers developed a new ionic liquid-based silane to enhance dental resins, improving resistance to acid attacks and bacterial degradation. This novel material shows promise for creating more durable and antimicrobial dental restorations.
Area of Science:
- Materials Science
- Biomaterials Engineering
- Dental Materials
Background:
- Dental resins currently face limitations in intraoral longevity due to susceptibility to acidic degradation and enzymatic breakdown.
- Streptococcus mutans, a primary cause of dental caries, poses a significant challenge to the durability of existing dental restorative materials.
Purpose of the Study:
- To synthesize an ionic liquid-based antibiofilm silane effective against Streptococcus mutans.
- To incorporate this silane into dental resins to create materials with enhanced resistance to biofilm formation and degradation.
- To evaluate the physical, mechanical, and biological properties of the modified dental resins.
Main Methods:
- Synthesis of an ionic liquid-based silane confirmed by FTIR, UV-vis, and NMR spectroscopy.
- Incorporation of the silane into dental resins, followed by characterization of degree of conversion, softening in solvent, flexural strength, and ultimate tensile strength.
- Evaluation of antibiofilm activity against Streptococcus mutans using viability assays and fluorescence microscopy, alongside cytotoxicity testing.
Main Results:
- The synthesized silane was successfully incorporated into dental resins, maintaining a comparable degree of conversion to commercial composites.
- Addition of at least 2.5 wt% silane reduced softening in solvent, while at least 5 wt% significantly reduced Streptococcus mutans viability with increased bacterial membrane damage.
- The modified resins demonstrated good biocompatibility and stability after six months of water storage, with no significant changes in mechanical properties over time.
Conclusions:
- The developed ionic liquid-based silane effectively enhances dental resins, providing improved resistance to solvent softening and significant antibiofilm properties against Streptococcus mutans.
- These novel dental materials exhibit biocompatibility and long-term stability, making them suitable for various dental applications.
- The potential exists for further development into antimicrobial polymeric layers for diverse surfaces, advancing novel biomaterials with enhanced therapeutic characteristics.
