Related Experiment Video

Updated: Jun 23, 2025

Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins
08:12

Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins

Published on: January 8, 2018

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Exploring the Role of Unconventional Post-Translational Modifications in Cancer Diagnostics and Therapy

Sayan Sharma1, Oindrila Sarkar1, Rajgourab Ghosh1

  • 1Department of Biotechnology, Amity University Kolkata, AIBNK, Kolkata, West Bengal, India.

Current Protein & Peptide Science
|June 24, 2024
PubMed

Insights

Unconventional post-translational modifications (PTMs) are vital in cancer. Understanding these PTMs offers new avenues for cancer diagnosis, prognosis, and targeted therapies.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Oncology

Background:

  • Unconventional post-translational modifications (PTMs) are increasingly recognized for their roles in cancer development.
  • These modifications, including O-GlcNAcylation and glutathionylation, impact critical cellular processes in cancer cells.

Purpose of the Study:

  • To provide a comprehensive review of unconventional PTMs in cancer.
  • To analyze their potential as diagnostic markers and therapeutic targets.

Main Methods:

  • Review of current literature on PTMs in cancer biology.
  • Highlighting advancements in analytical techniques like mass spectrometry and bioinformatics for PTM detection.

Main Results:

  • Unconventional PTMs are implicated in the dysregulation of signaling pathways in cancer.
  • Advanced techniques facilitate the identification of PTMs specific to cancer subtypes.

Conclusions:

  • Unconventional PTMs hold significant potential as biomarkers for improved cancer diagnosis.
  • Targeting these modifications could lead to the development of novel and potent cancer therapeutics.
Keywords:
Unconventional post-translational modificationsbiomarkerscancermass- spectrometryproteins.therapeutics

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